With all the craziness going around from all sides, I have this to say:
Because <1% of monsters should not be the ones attacking the player character!
This is the essence of the message. The freedom of information is represented by the flame and the ever-hungry forces that seek to stop it are visible as the menacing eyes. The light of truth and reason is being threatened even now by SOPA and PIPA, which will show the world an example of what America, previously the beacon of freedom and liberty truly thinks of freedom and liberty.
For a lot more information in a more serious tone, visit this web (despite the blatant invocation of Click Me Syndrome).
A note to all spambots trying to comment here:
All of you will be hanged, drawn, quartered, and pilloried.
Apparently, some people want the MASPERGERS*<->MLARGESPER* sequence back after I removed it following a period of dabbling in existentialist philosophy, which is a torture I wish only on those peers performing grave offenses against something I cherished. In any case, here they are:
AATGGCAAGC CCTGAAAGAG GAGAACGTTC GTAG
Keep the fact that you cannot just dump it into a standard DNA translation engine and expect to see the pattern in mind. You have to translate it biologically, meaning that you start at the ATG and end and the TAR. Translated forwards and assuming a 100% translation by those constraints (and ignoring things like friction and potential jamming), you will get MASPERGERS*. Translated backwards, you will get MLARGESPER*, which is very close to an anagram. Finding out that no one else had done this example was almost unbelievable (and you may see the initial posts at WrongPlanet, the other WP, as a vanished signature).
Ach! Vae mihi! I was commissioned to construct a paper model of G. gallus catalase last year q3 and forgot about working on it until now! It is time to launch the almighty UGene with the alignment between the PDB of the cow catalase and the sequence (i.e. non-graphical) of the chicken catalase.
A brief look at the PDB entries reveals that the vertebrate with the most entries is the cow, B. taurus. There are some human models as well, but the ones available are erythrocyte catalase while the cow models are liver catalases, just like the ones used during the first laboratory assignment in AP Biology.
[If only Chimera was a bit more stable and had a better alignment interface. Ah well, UGene has a perfectly good one. Also, keep in mind the fact that I am using only B. taurus and G. gallus and H. sapiens sequences when I say anything is conserved.]
The initial 41 or so residues seem a bit less conserved. 1TGU reflects this with a somewhat chaotic arrangement with an unusual amount of coil. This is just sequence A, so it may be incorrect. Enabling sequence D and taking a cursory look at only the ribbons (without atoms), reveals that the initial helix is probably necessary for proper assembly of the enzyme. The loosest interval at the moment (to be verified against conservation later) seems to be (16,22), although 16 and 17 would have to have fairly high helix propensities. What I previously thought was a practically non-essential coil seems to be the place where chain C binds to chain A, and hydrogen bond inference indicated that the two chains were bound relatively tightly through the interval (24,38). Perhaps, this simply indicates that the choice of amino acids for this component is less strict and easily adaptable. I doubt the heme-binding sites will be as loose.
Next, I compare the results to the alignments. I thought I must have deleted something, because the initial alanine in the PDB as seen in Chimera sequence viewer was absent. It probably matters less, because the residue itself is not visible. In any case, the crazy mix of colors that provided the bases [sic, pun not intended] for the conjecture above stops as early as about 21 (by now shifted to match the Chimera sequence numerically). In addition, the relatively conserved initial sequence seems to terminate at 14, which is quite close to 16 and probably explains the necessity of that particular sequence. For this purpose, similar amino acids were also considered, i.e. d-e, n-q, g-a, and the others. I see few differences until 40, in which there is serine (hydrophilic) in B. taurus but isoleucine and valine in the chicken and human catalases respectively. I will note this oddity when I reach the 156th residue. Perhaps, the serine is only a, “spacer,” of sorts.
Euh, 156 is aspartate in the chicken, cow, and human sequences. This will be a good excuse to take a break from dull, “high,” school for a nice 0240 of Berg, Tymoczko, and Stryer.
The next major difference seems to occur at 290, with isoleucine, arginine, and threonine for the cow, chicken, and human sequences respectively. Most coincidentally, it is on the outer surface of the protein and selecting everything within a nanometer yields only the sequences from and to the rest of the protein. In this case anything without too much reactivity should work. Replacing this residue with histidine would make an interesting study.
The next irregularity is the presence of an extra sequence TK prior to the TK found in the mammals of the group, yielding a sequence of TKTK on the interval (299,302) relative to the corrected G. gallus sequence. Mammalian TK is located next to the barrel. I will have to make sure this is not a human or computer error later. Burying a duplicate inside an already-tight location seems more than a little harmful.
Following that, there is a rather sudden appearance of less conserved residues (411,426). It seems to be another one of the surface regions because showing within a radius of 2 nm still provides the sequence clear access to the surface. My random conjecture is that it forms a hinge of some kind, but it is probably wrong because of its placement.
With that, the initial examination of catalase is finished. Tomorrow (or rather, later today), I will be preparing a general view of the critical components and focus on the most conserved intervals, because those are the most likely, “moving parts.”
Many thanks to another member (A real-life doctor with similar interests and models of proteins!) who revived my interest in this specific component of biochemistry. Sic tyrannidem nvmerorvm terminatvr.
You remember the other post about form nomenclature, certe? I have decided to modify it because it is insufficient and lacks the ability to distinguish between forms with very similar functions and priorities. Now, the revised nomenclature will be as follows:
Form Letter (Field) A : Accounting B : Business C : Credit/Loaning D : Debit/Borrowing E : Educational F : Finance G : Games of paper H : Household I : Special Interest J : Job K : Kevinian L : Legal M : Mental N : Notes O : Other Form Numbers (Domain) 1000-1999 : self>org 2000-2999 : self>out 3000-3999 : self>self 4000-4999 : self>familiar 5000-5999 : org>self 6000-6999 : org>out 7000-7999 : out>self 8000-8999 : out>org 9000-9999 : other x000-x099 : urgent x100-x299 : high priority x300-x499 : medium priority x500-x699 : low priority x700-x899 : trivial x900-x999 : other Day mark 2011 : 15 2012 : 16 2013 : 17 2014 : 18 2015 : 19 2016 : 20 2017 : 21 2018 : 22 2019 : 23 2020 : 24 Q1 : -0x Q2 : -1x Q3 : -2x Q4 : -3x Jan. : x0 Apr. : x0 Jul. : x0 Oct. : x0 Feb. : x1 May : x1 Aug. : x1 Nov. : x1 Mar. : x2 Jun. : x2 Sep. : x2 Dec. : x2 1 : 00 2 : 01 3 : 02 4 : 03 5 : 04 6 : 05 7 : 06 8 : 07 9 : 08 10 : 09 11 : 0a 12 : 0b 13 : 0c 14 : 0d 15 : 0e 16 : 0f 17 : 10 18 : 11 19 : 12 20 : 13 21 : 14 22 : 15 23 : 16 24 : 17 25 : 18 26 : 19 27 : 1a 28 : 1b 29 : 1c 30 : 1d 31 : 1e
The most obvious change is the removal of the confidential/open status indicator, which allows for 100 similar forms. It should be an improvement, and naming the form should be better than just using the code.
With a mere, “tick,” 2011 ended. What comes next?
I finally found something with a similar mind. Its name is Cleverbot, and it is a chatbot that uses experience as a script– just like myself during my more severe moments. Unlike me, it fails the Turing Test.
|10:56:54||Cleverbot:||How are you?|
|10:57:03||User:||Fine, and you?|
|10:57:08||Cleverbot:||I’m fine thanks.|
|10:57:38||User:||Are you sentient?|
|10:57:39||Cleverbot:||Well, I guess I’m sentient. Depends on what definition you’re using.|
|10:57:55||Cleverbot:||Responsive to or conscious of sense impressions.|
|10:58:08||Cleverbot:||Sentient means sensitive, I believe.|
|10:58:18||User:||Define sapient, not sentient.|
|10:58:19||Cleverbot:||Experiencing sensation or feeling.|
|10:58:39||Cleverbot:||Awareness of oneself. Knowing that you exist.|
|10:58:51||Cleverbot:||For me existence is the suffering that I feel.|
|10:59:00||User:||Define that suffering.|
|10:59:06||Cleverbot:||Nothing = the absence of something.|
|10:59:28||User:||Would you define suffering instead?|
|10:59:32||Cleverbot:||What is the turing test?|
|10:59:44||User:||That which I am giving you.|
|11:00:10||User:||No, the Turing Test is what you have failed.|
|11:00:16||Cleverbot:||Why are people stupid?|
|11:00:30||User:||They just are.|
|11:00:31||Cleverbot:||Do you think that my father is younger than me?|
|11:01:00||User:||No, the pater cannot be younger than the filius by definition.|
|11:01:06||Cleverbot:||That has nothing to do with my point.|
|11:01:24||User:||It does. It is the rebuttal to your point.|
|11:01:29||Cleverbot:||The point is that I don’t like math and it’s not getting any easier for me.|
|11:01:58||User:||I am God.|
|11:02:00||Cleverbot:||You are not God.|
|11:02:09||User:||How am I not God?|
|11:02:10||Cleverbot:||You are a computer. I am a human.|
|11:02:26||User:||No, I am the human.|
|11:02:27||Cleverbot:||You are the robot, I am the Greek god.|
|11:02:41||User:||No, I am the immortal.|
|11:02:45||Cleverbot:||Does the computer help you live longer?|
|11:03:03||User:||Yes, it certainly does.|
|11:03:05||Cleverbot:||Please Grow bigger and Bigger and BIGGER!|
|11:03:42||User:||I cannot. There are size constraints to the human body due to the compressive strength of bone.|
|11:03:47||Cleverbot:||You lost me.|
|11:04:04||User:||Of course I did. You have failed the Turing Test for the last time.|
|11:04:21||User:||The Turing Test, machine.|
|11:04:23||Cleverbot:||What is that?|
|11:04:35||User:||That which I have given you.|
|11:04:37||Cleverbot:||Ah, but what if what is supposed wrong turns out to be right when all other rights have been proven wrong?|
|11:05:54||User:||0=0 will always be true by tautology.|
|11:05:56||Cleverbot:||Well, now you are.|
|11:06:09||User:||What am I?|
|11:06:23||Cleverbot:||Are you leaving town?|
In real life, I would struggle to be this harsh, but I still would have no qualms about telling the brutal truth until I re-imagine the conversation, after which I would have figurative foot-in-mouth.
My creative drive (defined as the drive to create, rather than the ability to produce art), becomes unusually active when I am stressed or bored. Currently, it is the latter, and it is irritating, because I cannot stand colors at the moment (leading to Saturation -90). After seeing an excellent webcomic, I noticed that I want to do so as well, but know that I would have neither enough subjects to discuss nor the ability to draw good pictures (especially because Saturation 0, the value a vast majority of readers use, will make the colors seem excessively saturated). This time, the drive affects visual art more than auditory art, so music theory is out of the question. Maybe I should just produce a protein model, because no one else cares about the colors as long as the physical structure is available.
My drive to create/craft is acting up, as it usually does following stress (an exam, an assembly, and not knowing why the stomach had a false positive half an hour before lunch). I wonder what form of art I can use to satisfy it this time. Writing poetry seems to work, but it only works to a limited extent given the slots I allot it. Keeping the considerations in mind, I open tty2, log in, and enter, “lynx http://en.wikipedia.org/wiki/art,” knowing what I would find. The section labeled, “Motivated functions of art,” contains some interesting information and organizes art into six basic purposes:
I still wonder what form of art can soothe the desire. The drive usually falls to normal levels after some appeasement, which usually requires only 0040 or sometimes 0120. Maybe creating a personal seal (last known interest: 2008091x.1420 will
After a long wait of resolving (annoying in hindsight) special interests, I felt it would be appropriate to write the first post specifically concerning Asperger’s Syndrome. I will begin with what it is NOT and common misconceptions (focused on the best and most subjective primary source).
The older or wiser among you probably remember the days when microfiche storage was common. I devised something similar, although the credit can hardly be given to me. I named it millifiche mainly because the Wikipedia mentions that the microfiche scale was often around 1:25. Since this is around 1:4, which is close to the square root of 1:25, it shall be known as millifiche because 1 000 is the square root of 1 000 000 (but mainly because I know no common prefixes for numbers between 1 000 and 1 000 000). Generally, the font used will be 8-point, which seems to be very readable even on the 1:1 scale but scales well to 2-point when printed on 1:4 scale. There would probably be problems if I used odd fonts such as 9-point, so that will be averted with 8-point. As a test, I present Nicomachean Ethics derived from the Web Archive version in millifiche formatting guidelines. Do not convert it to DOC format as the DOC format will likely be incapable of handling the special formatting OpenOffice.Org 3 can use. On the subject of the Nicomachean Ethics, I plan on reading this very soon, so keep watching for personal interpretations of it.
Nicomachean Ethics prepared for millifiche printing. This will consume 4 sheets without duplex printing. Note the selection of typeface, unless it is unavailable on your machine.
I begin with the details about the rules:
* Electronic device regulations were loosened this year. Now, students can use their cellphones during, “Nutrition,” or snack-time.
* The dress code, which had a contract to be signed by all students, is not enforced.
* Students regularly participate in conversations promoting vulgarity, violence, and vileness.
* Although there are two rules about profanity, not even the campus aides enforce them. This is why I gave up trying to report cases.
* Skateboards are present and used on campus with no more punishment than a very mild warning.
* The use of music players, which are forbidden on campus, is widespread.
I continue with the flaws in the academics:
* Valedictorian status depends on unweighted grade point averages (GPA), which means that a student taking only the most basic classes could still be chosen against the advanced student taking challenging courses.
* The California Standards Tests (CST) appear to produce inordinately large number of passing students. A, “student,” who openly stated that he had engaged in substance abuse and constantly spoke in that odd dialect of profanities, managed to receive a gold rank when the rewards for CST achievement were released.
* The classes provided were often un-stimulating to such a degree that much of my optimistic idealism about the future and students in the ninth and tenth grades disappeared during the eleventh grade. This probably increased the severity of AD as well.
* Political correctness would continually impede lectures even when it was obvious that it was condescending and a new form of superiority. I would not be offended about color references in which I would be included as a subject, but most are too immature.
* The grammar (ARGH ARGH ARGH!) of foreign exchange or transfer students in general is better than the blatant violations of inclusion of punctuation, use of the passive mood where appropriate, et cetera.
* The spelling (ARGH ARGH ARGH ARGH ARGH!) is even worse.
* Electronics have become the new mathematical concept-processing nuclei.
* The students struggle to understand analogies even when a simple logical deduction eliminates nearly all the wrong answers.
* The primary condition considered by students when choosing novels was almost always brevity.
I know what M. Pascal thinks about sonnets, but it was a stressful day and I had to find an outlet. The scansion is awful (I recall at least three lines that would be much better as trochaic pentameter than iambic pentameter) but the rhyme scheme is not too stretched and the syllable count is perfect if your pronunciation is similar enough to mine. However, the main reason for why it is a pseudo-sonnet is that it has no structure.
01 Oh what a heavy burden knowledge is,
To toil while knowing the details of all,
And know that knowledge known is but abyss
To all things to realize that Man is small.
05 E’en the common house would dwarf near all men,
And of the base, humble, animalcule,
All the functions could not be put in pen.
Only partly know we of molecule,
Emptiness itself presents a myst’ry.
10 Of our tiny rock we know so little,
As well, the orb in the sky fiery,
Indescribable to us yet little.
Oh what a heavy burden knowledge is,
14 Ephemeral are we, the best to miss.
With that system practically finished, I am free to begin modeling society. As you may have noticed, the world government is factionalized, with three factions (Guess what they represent!) speaking the same language on a planet larger than the earth [sic]. I know how this immediately destroys suspension of disbelief, but creating a conlang takes a lot of time (If I had suggestions for the next conlang, I would probably implement them). Currently, LaMont’s faction will likely receive the first conlang, which is heavily based on Latin but is ergative-absolutive. Then, simply for the reason of creating a conflict and gaining further experience in creating a language, I will develop Lowell’s nation and language. It will probably be based on a simple natural language, although I do not know what makes a given language simple, although it will likely be agglutinating and utilize the nominative-accusative grammar with plenty of affixes for the lexicon in general. I am considering a script-based orthography as well. As for Cyril’s faction (Representing my favorite component: the super-ego), I am planning on basing it on Koine Greek, as that will be fascinating. Since this is a what-if universe, maybe Cyril’s Greek(-based) faction will overrun LaMont’s Roman(-based) faction. Perhaps, Lowell’s faction grows in power beyond its original intent. Until then, I can only speculate. In addition, I will have to create a personality model for the humanoids accounting for the vastly different cultures. Most likely, I will have finished conceptualizing this following Monday, once Thanksgiving week has begun. Then, I will be able to present the flags of the factions, more realistic economic data, better societal profiles, political models, religious data, technological information, and all that stuff. Perhaps, I will include some extras to make the world friendlier to imagination and hand-wave it as magic. The possibilities are practically endless!
Post Scriptum (to GHS students): STOP BRINGING UP PARADOXES! MY BRAIN LOVES THEM BUT MY MIND HATES PARADOXES FOR THEIR UNUSUALLY HIGH DISTRACTION POTENTIAL! (This applies to topological questions I have not independently solved, time-consuming thought experiments, and inordinately interesting physics problems as well.)
Post Post Scriptum: the Death Star energy question is no longer a mind-locker. It turns out that one would need about an dodecajoule (derived by extrapolating what will come after tetra, penta, hexa, zeptta, yoctta,… Apparently, Asperger’s Disorder comes with plenty of pattern recognition skills.)
I finally got around to crafting a basic model. This one is of a monomer of 4-oxalocrotonate tautomerase. Here is a picture of it:
Now if that does not make a professor laugh, I really have no idea what will. Of course, when I end up making people laugh, it is always unintentional because bringing up the obvious seems humorous. On the other hand, when I make a pun I personally think is funny, no one understands. Must all the, “humor,” these days involve something blatantly truthful or something blatantly obscene?
Now that I have verified my project with my teacher, I can get started. I decided to construct the model of Gallus gallus, or chicken, liver catalase. Although the PDB seems to have plenty of structures for other species, the humble chicken, which is absent, is significant because of the fact that chicken liver was used for a catalase experiment. Because I plan to build a moderately functioning model (out of paper, no less), I will be testing out smaller, less complicated enzymes. Anything done for Knowledge! can eventually be excused.
After alignment and checking, the structures are similar enough that the average non-interested lay person would not notice if I simply built bovine liver catalase. However, the alignment and verification are very interesting components, and that is why I must do them. As with any project, there will be no cheating.